C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 59/64 (2006.01) A61K 31/203 (2006.01) A61P 5/14 (2006.01) A61P 9/00 (2006.01) A61P 17/06 (2006.01) A61P 17/10 (2006.01) C07C 37/055 (2006.01) C07C 41/52 (2006.01) C07C 45/29 (2006.01) C07C 47/277 (2006.01) C07C 59/72 (2006.01) C07C 67/343 (2006.01) C07C 69/734 (2006.01) C07D 213/55 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01)
Patent
CA 2383565
The present invention provides a novel class of RXR modulator compounds that exhibit an improved pharmacologic profile relative to the profile of previously studied RXR modulators, including those that share common structural features with the presently claimed modulators. The present invention also provides synthetic methods for preparing these compounds as well as pharmaceutical compositions incorporating these novel compounds and methods for the therapeutic use of such compounds and pharmaceutical compositions.
La présente invention concerne une nouvelle catégorie de composés de modulateurs RXR présentant un profil pharmacologique amélioré par rapport à celui des modulateurs RXR étudiés antérieurement, y compris les modulateurs partageant des caractéristiques structurales communes avec les modulateurs de la présente invention. Cette dernière concerne également des procédés de synthèse permettant de préparer ces composés et des compositions pharmaceutiques contenant ces nouveaux composés, ainsi que des méthodes destinées à l'utilisation thérapeutique de ces composés et de ces compositions pharmaceutiques.
Ardecky Robert J.
Boehm Marcus F.
Chen Jyun-Hung
Faulkner Amy L.
Hamann Lawrence G.
Ligand Pharmaceuticals Incorporated
Smart & Biggar
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