S1p receptor modulating compounds and use thereof

Details S1p receptor modulating compounds and use thereof S1p receptor modulating compounds and use thereof

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61K 31/4427 (2006.01) A61P 1/00 (2006.01) A61P 3/10 (2006.01) A61P 19/02 (2006.01) A61P 35/02 (2006.01) A61P 37/06 (2006.01) C07D 401/10 (2006.01)

Patent

CA 2699417

The present invention relates to amides that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SIP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non- glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

La présente invention porte sur des amides qui ont une activité en tant qu'agents modulant les récepteurs S1P et sur l'utilisation de tels composés pour traiter des maladies associées à une activité des récepteurs S1P inappropriée. Les composés peuvent être utilisés en tant qu'immunomudulateurs, par exemple, pour traiter ou prévenir des maladies telles que des troubles auto-immuns et immunitaires apparentés comprenant le lupus érythémateux disséminé, les affections abdominales inflammatoires telles que la maladie de Crohn et la colite ulcérative, le diabète de type I, l'uvéite, le psoriasis, la myasthénie gravis, la polyarthrite rhumatoïde, la néphrose non glomérulaire, l'hépatite, la maladie de Behçet, la glomérulonéphrite, le purpura thrombopénique chronique, l'anémie hémolytique, l'hépatite et le granulome de Wegner; et pour traiter d'autres états.

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