Salicyclic acid derivatives as protease inhibitors

Details Salicyclic acid derivatives as protease inhibitors Salicyclic acid derivatives as protease inhibitors

C - Chemistry, Metallurgy

07

C

167/255, 260/475

C07C 65/01 (2006.01) C07C 65/19 (2006.01) C07C 65/21 (2006.01) C07C 65/40 (2006.01) C07C 69/84 (2006.01) C07D 295/03 (2006.01)

Patent

CA 1261868

ABSTRACT This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and there- by preventing or retarding the disease states caused by said degradation by administering compounds of the formula: Image wherein R1 is: a) hydrogen; or b) alkyl of 1 to 6 carbon atoms, inclusive; wherein R2 is: a) hydroxy; or b) alkoxy of 1 to 6 carbon atoms, inclusive; wherein R3 is: a) -C(O)R4; b) -CH(OH)R4; c) -CH2R4; or d) -CH=CHR4; wherein R4 is alkyl of 13 to 25 carbon atoms inclusive, or a pharmacologically acceptable salt thereof.

453852

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