Salt and polymorph of dpp-iv inhibitor

Details Salt and polymorph of dpp-iv inhibitor Salt and polymorph of dpp-iv inhibitor

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2633181

The invention is concerned with (2S)-1-{[1,1-Dimethyl-3-(4-pyridin-3-yl- imidazol-1-yl)-propylamino]-acetyl}-pyrrolidine-2-carbonitrile fumarate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as 5 medicament for the treatment of disorders which are associated with DPP-IV.

L~invention concerne le fumarate de (2S)-1-{[1,1-diméthyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propylamino]-acétyl}-pyrrolidine-2-carbonitrile et des polymorphes cristallins de ce composé. Ce composé et ses formes polymorphiques présentent des propriétés supérieures en comparaison des composés connus dans l~état de la technique. Il peut être utilisé en tant que médicament pour le traitement de troubles associés à DPP-IV.

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