C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 253/07 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2724742
The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2- yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2- fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b] [1,2,4]triazin-2-yl]benzamide, and salts thereof.
La présente invention concerne des sels dacide dichlorhydrique et dacide dibenzènesulfonique de linhibiteur de c-Met kinase, le 2-fluoro-N-méthyl-4-[7-(quinoléin-6-ylméthyl)-imidazo[1,2-b][1,2,4]- triazin-2-yl]benzamide, et leurs compositions pharmaceutiques, utiles dans le traitement du cancer et dautres maladies associées au dérèglement des voies des kinases. La présente invention concerne en outre des procédés et des intermédiaires de préparation du 2-fluoro-N-méthyl-4-[7-(quinoléin-6-ylméthyl)imidazo[1,2-b][1,2,4]- triazin-2-yl]benzamide et de ses sels.
Liu Pingli
Pan Yongchun
Qiao Lei
Weng Lingkai
Zhou Jiacheng
Incyte Corporation
Osler Hoskin & Harcourt Llp
LandOfFree
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