C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/81 (2006.01) A61P 31/18 (2006.01) C07D 217/26 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2590141
Analogs of saquinavir functionalized at the quinoline portion of the molecule are described. These include pyridyl analogs (replacing the quinoline ring) with a functional handle out of the ring allowing for elaboration with linkers terminated by a functional group, such as an activated ester which are useful for attaching the molecule to other entities such as proteins, polysaccharides, and the like. Analogs of saquinavir derivatized out of the quinoline ring are also described. Further described are antibodies generated in response to pyridyl analogs and quinoline analogs of saquinavir.
Cette invention concerne des analogues de saquinavir fonctionnalisés au niveau de la partie quinoléine de la molécule. Ces analogues comprennent des analogues pyridyle (remplaçant l'anneau quinoléine) comportant une poignée fonctionnelle hors de l'anneau permettant une élaboration avec des lieurs se terminant par un groupe fonctionnel, tel qu'un ester activé, qui permettent de fixer la molécule à d'autres entités telles que des protéines, des polysaccharides et analogue. Cette invention concerne également des analogues de saquinavir dérivés de l'anneau quinoléine. Cette invention concerne en outre des anticorps générés en réponse aux analogues pyridyle et des analogues quinoléine de saquinavir.
Hui Raymond A.
Root Richard T.
Sigler Gerald F.
Yuan Wie
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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