Scaffolds for organ reconstruction and augmentation

A - Human Necessities – 61 – F

Patent

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A61F 2/00 (2006.01)

Patent

CA 2641733

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

L'invention concerne des structures formant échafaudage naturelles ou synthétiques biocompatibles destinées à la reconstruction, à la réparation, à l'augmentation ou au remplacement d'organes ou de structures tissulaires d'un patient nécessitant un tel traitement. Ces structures formant échafaudage sont formées pour adopter la forme d'au moins une partie de l'organe ou de la structure tissulaire susmentionnée et peuvent être ensemencées par au moins une population cellulaire. L'invention concerne également des éléments d'insertion, de réception et des ports destinés à fixer des vaisseaux tubulaires sur ces échafaudages néorganiques. Les échafaudages ensemencés de l'invention sont implantés dans le patient sur un site nécessitant le traitement susmentionné, pour former un organe ou une structure tissulaire organisée. Ces échafaudages peuvent être utilisés pour former des organes ou des tissus, notamment des vessies, des urètres, des valves et des vaisseaux sanguins.

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