Scorpion toxins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C12N 1/00 (2006.01) C12N 15/82 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2351870

This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel agonists. The invention also relates to the construction of a chimeric gene encoding all or a portion of the K-channel agonists, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the K-channel agonists in a transformed host cell.

La présente invention concerne un fragment d'acides nucléiques qui a été isolé et qui code des toxines de scorpions, lesquelles toxines sont des agonistes du canal potassium. L'invention concerne également la construction d'un gène chimérique codant tout ou partie des agonistes du canal potassium, selon l'orientation sens ou antisens. En l'occurrence, l'expression de ce gène chimérique aboutit à la production de niveaux modifiés d'agonistes du canal potassium dans une cellule hôte transformée.

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