Secretory molecules

Details Secretory molecules Secretory molecules

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2419943

The present invention provides purified secretory polynucleotides (sptm) and the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.

Cette invention a trait à des polynucléotides sécréteurs purifiés (sptm) et aux polypeptides (SPTM) codés par ceux-ci. Elle concerne également l'utilisation de sptm, ou de compléments, ou d'oligonucléotides, ou de fragments de ces derniers dans des épreuves diagnostiques. L'invention concerne en outre des vecteurs et des cellules hôtes contenant des sptm aux fins de l'expression de SPTM. L'invention concerne aussi l'utilisation de SPTM isolées et purifiées pour induire des anticorps et pour examiner des bibliothèques de composés et l'utilisation d'anticorps anti-SPTM dans des épreuves diagnostiques. L'invention concerne enfin des jeux ordonnés de microéchantillons contenant des sptm et des procédés d'utilisation.

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