Secretory molecules

Details Secretory molecules Secretory molecules

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2447212

The invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTMto induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.

L'invention concerne des polynucléotides sécrétoires purifiés (SPTM), ainsi que les polypeptides (SPTM) codés par ces SPTM. Cette invention concerne également l'utilisation de SPTM, ou de compléments, d'oligonucléotides ou encore de fragments de ces derniers dans des dosages diagnostiques. Cette invention se rapporte en outre à des vecteurs et des cellules hôtes contenant des SPTM pour l'expression de SPTM, à l'utilisation de SPTM isolés et purifiés pour induire des anticorps et cribler des bibliothèques de composés ainsi qu'à l'utilisation d'anticorps anti-SPTM dans des dosages diagnostiques. La présente invention concerne enfin des jeux ordonnés de microéchantillons contenant des SPTM et des méthodes d'utilisation.

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