Selective acylation of .epsilon.-amino groups

Details Selective acylation of .epsilon.-amino groups Selective acylation of .epsilon.-amino groups

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) C07K 1/13 (2006.01)

Patent

CA 2205061

The present invention relates to the acylation of proteins. More particularly, the invention relates to a one-step process for selectively acylating the free .epsilon.-amino group of insulin, insulin analog, or proinsulin in the presence of a free .alpha.-amino group.

La présente invention concerne l'acylation des protéines. Plus précisément, elle porte sur un processus en une seule étape d'acylation sélective du groupe .epsilon.-amino libre suivant formé par insuline, analogue de l'insuline, ou proinsuline en présence d'un groupe .alpha.-amino.

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