Selective thyroid hormone analogs

Details Selective thyroid hormone analogs Selective thyroid hormone analogs

C - Chemistry, Metallurgy

07

C

C07C 59/70 (2006.01) A61K 31/192 (2006.01) C07C 59/90 (2006.01) C07C 69/76 (2006.01)

Patent

CA 2290622

Selective thyroid hormone agonists are disclosed that are highly selective for the TR.beta. subtype with high binding affmity. Methods of using such agonists and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation. The present invention relates to compounds of the following formula. (SEE ABOVE FORMULA)

L'invention concerne des agonistes d'hormones thyroïdiennes sélectifs hautement sélectifs pour le sous-type TR beta à haute affinité de liaison. L'invention concerne également des méthodes d'utilisation de ces agonistes, ainsi que des compositions pharmaceutiques les contenant et de nouveaux procédés de préparation des agonistes.

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