A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/40 (2006.01) A61K 31/7088 (2006.01) A61K 39/112 (2006.01) A61K 39/39 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2603199
The present invention relates to compositions and methods for blocking entry of Shigella into a cell of an animal, to therefore providing protection against, or reduce the severity of Shigella infections. More particularly it relates to the use of the IpaD protein obtained from natural sources and/or through synthesis or recombinant technology, and conjugates thereof to induce neutralizing antibodies having protective activity against several serotypes of Shigella, in particular S. flexneri. The composition of the invention is useful to prevent and/or treat shigellosis caused by a bacterium of the Shigella family.
Allaoui Abdelmounaaiem
Boekema J. Egbert
Botteaux Anne
Parsot Claude
Sani Musa
Institut National de La Sante Et de La Recherche Medicale (inser
Institut Pasteur de Paris
Robic
Universite Libre de Bruxelles (ulb)
University Of Groningen
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