Sirtuin modulating imidazothiazole compounds

Details Sirtuin modulating imidazothiazole compounds Sirtuin modulating imidazothiazole compounds

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/429 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2692099

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

L'invention concerne de nouveaux composés modulant les sirtuines et leurs méthodes d'utilisation. Ces composés modulant les sirtuines peuvent être utilisés pour prolonger la durée de vie d'une cellule et pour traiter et/ou prévenir un grand nombre de maladies et de troubles, y compris, par exemple, des maladies et des troubles liés au vieillissement et au stress, le diabète, l'obésité, des maladies neurodégénératives, une maladie cardiovasculaire, des troubles de la coagulation sanguine, l'inflammation, le cancer, et/ou les bouffées vasomotrices, ainsi que des maladies ou des troubles pouvant bénéficier d'une activité mitochondriale plus intense. L'invention concerne également des compositions comprenant un composé modulant les sirtuines, combiné à un autre agent thérapeutique.

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