C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/107 (2006.01) A61K 38/00 (2006.01) C07K 14/00 (2006.01)
Patent
CA 2739445
Site-specific modifications of proteins at their N-termini are provided. In particular, a chemical modification of proteins at their N-termini via a transamination reaction to form homogeneous adducts such as, the corresponding oxime derivatives is provided. Methods of making and using the adducts in radio-labelling, molecular imaging applications, and treatment of disorders such as cancer, Crohn's disease, arthritis, atherothrombosis and plaque rupture are also provided.
La présente invention concerne des modifications spécifiques de site de protéines sur leur N-terminaux. En particulier, l'invention porte sur une modification chimique de protéines sur leur N-terminaux par l'intermédiaire d'une réaction de transamination, pour former des adduits homogènes tels que les dérivés d'oxime correspondants. L'invention porte en outre sur des procédés de réalisation et d'utilisation d'adduits dans le radio-marquage, des applications d'imagerie moléculaire, et le traitement de troubles tels que le cancer, la maladie de Crohn, l'arthrite, l'athérothrombose et la rupture de la plaque.
Krantz Alexander
Yu Peng
Advanced Proteome Therapeutics Inc.
Borden Ladner Gervais Llp
LandOfFree
Site specific n-terminal modifications of proteins and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Site specific n-terminal modifications of proteins and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Site specific n-terminal modifications of proteins and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1348036