C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2289906
The invention describes amino acid residues of the Smad2 protein which are important for phosphorylation activity, and Smad2 polypeptide fragments and biologically functional variants thereof. Included and dominant-negative variants of Smad2 and antibodies relating thereto. Also included are nucleic acids which encode such variants. Antibodies which selectively bind pathway- restricted Smad proteins phosphorylated at the C-terminal tail also are provided. Methods and products for using such nucleic acids and polypeptides also are provided.
L'invention porte sur des résidus d'acides aminés de la protéine Smad2 importants pour l'activité de phosphorylation, et sur des fragments du polypeptide Smad2 et leurs variantes à fonction biologique, y compris les variantes dominantes/négatives de la protéine Smad2, et les anticorps associés. Elle porte également sur les acides nucléiques codant pour de telles variantes, sur des anticorps phosphorylés à l'extrémité C-terminale se fixant sélectivement aux protéines Smad à mécanisme restreint, et sur les procédés et produits d'utilisation de ces acides nucléiques, et polypeptides.
Dijke Peter Ten
Engstrom Ulla
Heldin Carl-Henrik
Piek Ester
Souchelnytskyi Serhiy
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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