C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2497902
It is intended to disclose a novel polypeptide binding to SMG-1, a polynucleotide encoding the same, and a system for screening a substance which artificially controls an mRNA surveillance mechanism. The above-described polypeptide has an activity of binding to SMG-1, an activity of being phosphorylated by SMG-1 and an activity controlling the action of SMG-1 through the above-described activities.
La présente invention concerne un nouveau polypeptide de liaison à la SMG-1, un polynucléotide codant pour ladite protéine et un système de criblage d'une substance qui régule de manière artificielle un mécanisme de surveillance d'ARNm. Le polypeptide susdécrit présente une activité de liaison à la SMG-1, une activité de phosphorylation par la SMG-1 et une activité de régulation de l'action de la SMG-1 par l'intermédiaire des activités susdécrites.
Ohnishi Tetsuo
Ohno Shigeo
Yamashita Akio
City Of Yokohama
Fetherstonhaugh & Co.
Japan Science And Technology Agency
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