C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2623490
By a computer search for upstream promoter elements (DSE, PSE) typical of small nuclear RNA (snRNA) genes, we have identified a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of odne of them, we provide evidence for the existence of a sense/antisense-based gene regulation network where part of the Pol III transcriptome could control its Pol II counterpart.
Une recherche informatique d'éléments promoteurs en amont (DSE, PSE), typiques des petits gènes ARN nucléaires (ARNsn), a permis d'identifier un nombre d'unités transcriptionnelles putatives inconnues auparavant dont les produits prédits sont de nouveaux ARN non codants présentant une homologie avec les gènes de codage des protéines. En élucidant la fonction de l'un d'eux, on démontre l'existence d'un réseau de régulation génique sens/antisens dans lequel une partie du transcriptome Pol III pourrait réguler sa contrepartie Pol II.
Dennison Associates
Universita Degli Studi Di Genova
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