C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/715 (2006.01)
Patent
CA 2569867
The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL- 17A and IL-17F. The present invention includes soluble ZcytoR14, anti-ZcytoR14 antibodies and binding partners, as well as methods for antagonizing IL-17F, IL-17A or both IL-17A and IL-17F using such soluble receptors, antibodies and binding partners.
La présente invention a trait à des molécules de polypeptides de blocage, d'inhibition, de réduction, d'antagonisation ou de neutralisation de l'activité de IL-17F, IL-17A, ou de IL-17A et IL-17F. IL-17A et IL-17F sont des cytokines impliquées dans des processus inflammatoires et dans la maladie humaine. Le ZcytoR14 est un récepteur commun pour IL-17A et IL-17F. La présente invention a également trait à des ZcytoR14 solubles, des anticorps anti-ZcytoR14 et des partenaires de liaison, ainsi qu'à des procédés pour l'antagonisation de IL-17A et IL-17F. IL-17A et IL-17F mettant en oeuvre de tels récepteurs solubles, anticorps et partenaires de liaison.
Bilsborough Janine
Burkhead Steven K.
Gao Zeren
Jaspers Stephen R.
Kuestner Rolf E.
Osler Hoskin & Harcourt Llp
Zymogenetics Inc.
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