Somatostatin receptor 1 and/or 4 selective agonists and...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 311/19 (2006.01) A61K 31/18 (2006.01)

Patent

CA 2541530

The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.

L'invention concerne des peptidomimétiques à base d'(hétéro)arylsulfonylamino de formule (I), dans laquelle R1, R2, R3, A, B, D, Q, k et n sont tels que définis dans la description ou un sel ou un ester acceptable sur le plan pharmaceutique de ceux-ci. Les composés de formule (I) possèdent une affinité et une sélectivité élevées pour les sous-types du récepteur de la somatostatine SSTR1 et/ou SSTR4 et ils peuvent être utilisés pour le traitement ou le diagnostic de maladies ou d'états dans lesquels une interaction avec SSTR1 et/ou SSTR4 est utile.

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