Specific binding proteins and uses thereof

Details Specific binding proteins and uses thereof Specific binding proteins and uses thereof

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2447139

The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild- type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID Nos: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

L'invention concerne des éléments de liaison spécifiques, notamment des anticorps et des fragments actifs de ceux-ci, qui reconnaissent un aberrant modifié de manière post-translationnelle, en particulier une forme aberrante glycosylée d'EGFR. Ces éléments de liaison, notamment des anticorps et des fragments de ceux-ci, ne se lient pas à EGFR sur des cellules normales en l'absence d'amplification du gène de type sauvage, mais ils peuvent se lier à de2-7 EGFR au niveau d'un épitope distinct du peptide de jonction. Des anticorps de ce type sont illustrés par le nouvel anticorps 806, dont les séquences VH et VL sont représentées comme séquences SEQ ID Nos: 2 et 4, leurs anticorps chimériques étant illustrés par ch806.

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