Spheroids

Details Spheroids Spheroids

A - Human Necessities

61

K

167/169

A61K 9/16 (2006.01) A61K 47/38 (2006.01)

Patent

CA 1310584

ABSTRACT A controlled release pharmaceutical composition contains a number of spheroids, the spheroids containing a water-insoluble drug dispersed in a controlled release matrix. The matrix contains between 70% and 99.5% (by weight) of microcrystalline cellulose, between 0.5% and 4% (by weight) of a cellulose derivative and, optionally, up to 26% of a sugar or a sugar alcohol. The water insoluble drug must dissolve in water (pH 5) at 20°C to a concentration of less than 1.0mg ml-1, preferably less than 0.5mg ml-1. Preferred drugs are non-steroidal anti-inflammatory agents, especially fenprofen calcium, ibuprofen, ketoprofen, naproxen, diclofenac sodium, fenbufen, flurbiprofen, indomethacin, oxyphenbutazone, phenylbutazone or piroxicam.

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