Sphingenine and derivative thereof

Details Sphingenine and derivative thereof Sphingenine and derivative thereof

C - Chemistry, Metallurgy

07

C

260/557.3, 260/6

C07C 69/18 (2006.01) C07C 43/178 (2006.01) C07C 217/46 (2006.01) C07C 233/18 (2006.01) C07C 247/08 (2006.01)

Patent

CA 2004875

Abstract of the Disclosure A sphingenine and derivatives thereof herein provided are represented by the following general formulas (I) and (II): Image (I) Image (II) in the formulas (I) and (II), R1 represents a hydrogen atom, an acetyl group or a methanesulfonyl group; R2 represents a hydrogen atom or an ethoxyethyl group; R3 represents an azido group, an amino group, an alkylamido group, an arylamido group, an aralkylamido group or a tetracosanamido group; R' represents a hydrogen atom or an ethoxyethyl group; and n is an integer ranging from 1 to 22. These sphingenine and derivatives thereof are very useful as intermediates for synthesizing glycolipids and gangliosides which are effective as markers of tumours, in particular, in the preparation of ceramide parts of the glycolipids and gangliosides.

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