Spiro compounds and methods for the modulation of chemokine...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/10 (2006.01) A61K 31/437 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2573951

Novel compounds represented by formula (I): wherein Y, Z, X, W, R1, R2 and R3 are as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity and the treatment or prevention of diseases associated therewith.

La présente invention concerne de nouveaux composés représentés par la formule (I) : dans laquelle Y, Z, X, W, R1, R2 et R3 sont tels que définis dans cette invention, ou des sels, des hydrates ou des solvates de ceux-ci, acceptables d'un point de vue pharmaceutique, qui sont utilisés pour moduler une activité de récepteur de chimiokine CCR5 et pour traiter ou prévenir des maladies qui y sont associées.

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