Spiro-imidazolone derivatives as glucagon receptor antagonists

Details Spiro-imidazolone derivatives as glucagon receptor antagonists Spiro-imidazolone derivatives as glucagon receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 235/02 (2006.01) A61K 31/4184 (2006.01) A61K 31/4188 (2006.01) A61K 31/4439 (2006.01) A61K 31/4453 (2006.01) A61K 31/47 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2738663

The present invention relates to compounds of the general formula: (I) wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.

La présente invention concerne des composés de formule générale (I) dans laquelle le cycle A, le cycle B, R1, R3, Z, L1 et L2 sont choisis indépendamment les uns des autres et sont tels que définis dans l'invention, ainsi que des compositions contenant lesdits composés, et des procédés d'utilisation de ces composés en tant qu'antagonistes des récepteurs du glucagon et pour le traitement ou la prévention du diabète de type 2 et des affections apparentées.

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