Spirocyclic piperidines as mch1 antagonists and uses thereof

Details Spirocyclic piperidines as mch1 antagonists and uses thereof Spirocyclic piperidines as mch1 antagonists and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 491/107 (2006.01) A61K 31/438 (2006.01) A61P 3/04 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 221/20 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2485375

This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.

La présente invention concerne des composés qui sont des antagonistes sélectifs des récepteurs de l'hormone-1 de concentration de mélanine (MCH-1). L'invention concerne une composition pharmaceutique comprenant une quantité thérapeutiquement efficace du composé selon l'invention et un support pharmaceutiquement acceptable. L'invention concerne une composition pharmaceutique obtenue par combinaison d'une quantité thérapeutiquement efficace du composé selon l'invention et d'un support pharmaceutiquement acceptable. L'invention concerne en outre un procédé de préparation d'une composition pharmaceutique consistant à combiner une quantité thérapeutiquement efficace du composé selon l'invention et un support pharmaceutiquement acceptable. L'invention concerne également une méthode de réduction de la masse corporelle d'un sujet consistant à administrer au sujet une quantité efficace d'un composé selon l'invention pour réduire la masse corporelle du sujet. L'invention concerne encore une méthode de traitement d'un sujet souffrant de dépression et/ou d'anxiété, consistant à administrer au sujet une quantité efficace d'un composé selon l'invention pour traiter la dépression et/ou l'anxiété du sujet. L'invention concerne enfin une méthode de traitement d'un sujet souffrant de troubles urinaires.

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