Src kinase inhibitor compounds

Details Src kinase inhibitor compounds Src kinase inhibitor compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/506 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07F 9/59 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2376957

Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogenesis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.

L'invention concerne des composés de pyrimidine de la formule (I) ou leurs sels, hydrates, slovates, formes cristallines ou diastéréomères individuels pharmaceutiquement acceptables, et des compositions pharmaceutiques contenant ces composés. Les composés de l'invention sont des inhibiteurs des enzymes tyrosine-kinase et, en tant que tels, conviennent pour la prophylaxie ou le traitement de troubles associés à la protéine tyrosine-kinase, tels que les maladies immunitaires, les troubles hyperproliférants et autres troubles (comme le cancer, l'angiogenèse, l'athérosclérose, le rejet de la greffe, l'arthrite rhumatoïde et la psoriasis) dans lesquels on estime qu'une action inappropriée de la protéine kinase joue un rôle.

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