A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7052 (2006.01) A61K 9/20 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61P 31/04 (2006.01) C09K 15/06 (2006.01)
Patent
CA 2463619
Compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin compositions and methods of making such formulations are also described.
L'invention concerne des compositions et des procédés de stabilisation de compositions de l'azithromycine. Les compositions d'azithromycine comprennent un adjuvant d'azithromycine et une quantité efficace stabilisante d'un antioxydant destinés à améliorer la résistance de l'azithromycine à la dégradation. La co-précipitation ou la co-concentration de l'azithromycine et d'un antioxydant sont des modes préférés de réalisation d'un adjuvant intime. L'invention concerne des formulations pharmaceutiques comprenant une composition d'azithromycine stabilisée ainsi que des procédés de production desdites formulations.
Hrakovsky Julia
Khondo Lev
Lessen Tania
Mathivanan Mathi
Pesachovich Michael
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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