Stabilized bioactive preparations and methods of use

Details Stabilized bioactive preparations and methods of use Stabilized bioactive preparations and methods of use

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 9/12 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 9/72 (2006.01) A61K 45/08 (2006.01)

Patent

CA 2304820

Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.

La présente invention concerne des dispersions stabilisées utilisées pour administrer un agent bioactif. De préférence, ces dispersions comprennent une pluralité de microstructures perforées dispersées dans un milieu de suspension qui renferme généralement un composé fluoré liquide. Puisque les variations de densité entre les particules suspendues et le milieu de suspension sont réduites au minimum et les forces d'attraction entre les microstructure atténuées, les dispersions précitées sont particulièrement résistantes à la dégradation, telle que par sédimentation ou par floculation. Dans les modes de réalisation préférentiels, les dispersions stabilisées peuvent être directement administrées au poumon d'un patient en utilisant un tube endotrachéal ou un bronchoscope.

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