C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A61K 31/131 (2006.01) A61K 31/136 (2006.01) A61K 31/137 (2006.01) A61K 31/192 (2006.01) A61K 31/198 (2006.01) A61K 31/205 (2006.01) A61K 31/4172 (2006.01) A61K 31/519 (2006.01) A61K 31/714 (2006.01) A61K 31/737 (2006.01) C12N 15/67 (2006.01) C12N 15/87 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2333331
This invention provides methods and chemical agents for enhancing transient expression in eukaryotic cells. Also provided are a model system for achieving prolonged transient expression in solid tumors, a means for culturing hepatocytes without feeder cells or an extracellular matrix bonded to the substratum, a method for manipulating cellular metabolism to reduce the consumption of glucose and a means for inducing the secretion of an endogenous phosphatase activity.
La présente invention concerne des procédés et agents permettant de renforcer l'expression transitoire dans des cellules eucaryotes. L'invention concerne également un système de modélisation servant à obtenir une expression transitoire prolongée dans les tumeurs solides. L'invention concerne aussi des moyens permettant de cultiver des hépatocytes sans cellules nourricières ou matrice extracellulaire liée au substrat. L'invention concerne en outre un procédé de manipulation du métabolisme cellulaire visant à réduire la consommation de glucose par les cellules. L'invention concerne enfin un moyen permettant d'induire la sécrétion d'une activité phosphatase endogène.
Goffe Adeelia S.
Goffe Randal A.
Genespan Corporation
Mbm & Co.
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