Stable igg4 antibodies

Details Stable igg4 antibodies Stable igg4 antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2688275

The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe re sidue at position (405) or the Lys residue at position (370).

La présente invention concerne de nouveaux anticorps IgG4 stabilisés, des procédés de production de tels anticorps et l'utilisation de tels anticorps en tant que médicament. Un aspect principale de l'invention porte sur un anticorps IgG4 stabilisé qui comprend une chaîne lourde et une chaîne légère, ladite chaîne lourde se composant d'une région humaine IgG4 constante dont les résidus Arg en position (409), Phe en position (405) ou Lys en position (370) sont substitués.

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