Stable non-hygroscopic crystalline form of...

C - Chemistry – Metallurgy – 07 – K

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C07K 5/083 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07D 211/34 (2006.01) C07D 211/70 (2006.01) C07K 5/02 (2006.01) C07K 5/062 (2006.01)

Patent

CA 2263647

The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperidin-4--yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-.beta.- cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of formula (II) wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.

Forme cristalline stable non hygroscopique du composé anti-thrombotique N- [N-[N-(4-(piperidin-4-yl) butanoyl)-N-éthylglycyl]-(L)-aspartyl]-(L)-.beta.-cyclohexylalanine amide, procédés pour préparer cette forme cristalline stable, composition pharmaceutique et intermédiaires de ce composé. L'invention porte également sur des procédés pour préparer un composé représenté par la formule (II) dans laquelle A, B, Z, E?1¿, E?2¿, G, R, m, n et p sont conformes aux définitions du descriptif.

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