A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2565168
The present invention relates to an inclusion complex containing a benzimidazole derivative with excellent storage stability and a method of its preparation. In particular, the present invention relates to an inclusion complex containing a benzimidazole derivative with improved storage stability and a method of its preparation, where an inclusion complex is manufactured by performing an inclusion reaction by combining a benzimidazole derivative, cyclodextrin and a water-soluble polymer in an aqueous alkali solution in order to be formulated after stabilizing an acid-unstable benzimidazole derivative.
La présente invention concerne un complexe d'inclusion contenant un dérivé de benzimidazole présentant une excellente stabilité au stockage ainsi que son procédé de préparation. Plus particulièrement, la présente invention concerne un complexe d'inclusion contenant un dérivé de benzimidazole présentant une stabilité au stockage améliorée ainsi que son procédé de préparation. Un complexe d'inclusion est fabriqué au moyen d'une réaction d'inclusion par combinaison d'un dérivé de benzimidazole, d'une cyclodextrine et d'un polymère hydrosoluble dans une solution alcaline aqueuse en vue d'une préparation après la stabilisation d'un dérivé de benzimidazole instable en milieu acide.
Choi Jin Young
Hwang Yong Youn
Kim Jae Sun
Kim Nam Ho
Kum Do Seung
Blake Cassels & Graydon Llp
Sk Chemicals Co. Ltd.
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