C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/517 (2006.01)
Patent
CA 2632556
The present invention relates to a stable crystalline form of N-(3- ethynylphenyl)-6,7--bis (2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the A polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph A form of N-(3--ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride, as well as other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
La présente invention a pour objet une forme cristalline stable de chlorhydrate de N-(styrèn-3- yl)-6,7-bis(2-méthoxyéthoxy)quinazolin-4-amine appelée polymorphe A, sa production sous forme quasiment pure et son utilisation. La présente invention a aussi pour objet des compositions pharmaceutiques contenant le polymorphe A stable du chlorhydrate de N-(styrèn-3- yl)-6,7-bis(2-méthoxyéthoxy)quinazolin-4-amine, ainsi que d'autres formes de ce composé, et des méthodes de traitement de maladies à évolution hyperchronqiue, comme le cancer, en administrant ce composé.
Connell Richard D.
Ferrante Karen J.
Foster Barbara A.
Kajiji Shama M.
Morin Michael J.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
Osi Pharmaceuticals Inc.
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