Stable s-nitrosothiols, method of synthesis and use

Details Stable s-nitrosothiols, method of synthesis and use Stable s-nitrosothiols, method of synthesis and use

C - Chemistry, Metallurgy

07

D

C07D 211/54 (2006.01) A61K 31/44 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2673988

The present invention relates to stable S-nitrosothiols derivatives of formula (I) having vasodilating effect and which inhibit the aggregation of the platelets and which therefore are useful for the preparation of medicaments for treatment of NO related diseases. The invention also relates to a process for the synthesis of the compounds of formula (I) and to intermediate compounds thereof.

La présente invention porte sur des dérivés de S-nitrosothiols stables représentés par la formule (I) qui ont un effet vasodilatateur et qui inhibent l'agrégation plaquettaire et qui, par conséquent, sont utiles pour la préparation de médicaments pour le traitement de maladies associées à NO. L'invention porte également sur un procédé pour la synthèse des composés de formule (I) et sur des composés intermédiaires de ceux-ci.

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