Steap-related protein

Details Steap-related protein Steap-related protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 1/32 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2441082

The invention provides a cDNA which encodes a STEAP-related protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of prostate cell proliferative disorders, particularly prostate hyperphasia and prostate cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

L'invention concerne de l'ADNc codant une protéine associée à la STEAP. L'invention concerne également l'utilisation de l'ADNc, de fragments, de compléments et de variants de celle-ci et de la protéine codée, de sections de celle-ci et d'anticorps de ceux-ci pour le diagnostic et le traitement des troubles proliférants de la cellule de la prostate, en particulier l'hyperphasie de la prostate et du cancer de la prostate. L'invention concerne également les vecteurs d'expression et des cellules hôtes pour la production de la protéine et un système de modèle transgénique.

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