C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
167/196, 260/68
C07J 5/00 (2006.01) A61K 31/57 (2006.01) C07J 13/00 (2006.01)
Patent
CA 2011282
NOVEL STEROID DIOLS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME Abstract The invention relates to novel .DELTA.14-16.alpha.,17-dihydroxy- pregnane derivatives of general formula (I), Image (I) wherein A stands for hydrogen, hydroxyl or trifluoroacetoxy group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen, benzoyl or C1-8alkanoyl group; and Image represents a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess valuable antiinflammatory effects. Thus, they can be used as active ingredients in antiinflammatory pharmaceutical compositions and, on the other hand, for the preparation of other, therapeutically useful steroid derivatives.
Boor Anna
Csorgei Janos
Fekete Gyorgy
Forgacs Lilla
Hajos Gyorgy
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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