Substituted 1,4-diazepines and uses thereof

Details Substituted 1,4-diazepines and uses thereof Substituted 1,4-diazepines and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2523561

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I as defined herein, with R 1 to R 8 and X as defined herein or a solvate, hydrate or pharmaceutically acceptable salt thereof.

L'invention concerne de nouvelles 1,4-diazépines, des compositions pharmaceutiques contenant ces diazépines, ainsi que leur utilisation comme inhibiteurs d'interactions HDM2-p53. Les composés selon l'invention incluent des composés de formule (I), dans laquelle R?1 ¿à R?8 ¿et X sont tels que définis dans la description, ou un solvate, un hydrate ou un sel pharmaceutiquement acceptable de ces composés.

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