Substituted 1-pyrimidinylacetamide compounds

Details Substituted 1-pyrimidinylacetamide compounds Substituted 1-pyrimidinylacetamide compounds

C - Chemistry, Metallurgy

07

D

C07D 239/47 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 239/46 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07F 9/6512 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2076226

The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use. The compounds of formula I have the structure: (see formula I) wherein R0 is C1-5alkyl, and R and R6 represent different radicals.

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