Substituted...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 409/10 (2006.01) A61K 31/381 (2006.01) A61P 35/00 (2006.01) C07D 333/10 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2757573

Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.

Les 4-amino-5-benzoyl-2-(phénylamino)thiophène-3-carbonitriles substitués et 4-amino-5-benzoyl-2-(phénylamino)thiophène-3-carboxamides substitués ci-décrits et leurs sels sont des inhibiteurs de polymérisation de la tubuline, utiles dans le traitement du cancer.

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