Substituted amides

Details Substituted amides Substituted amides

C - Chemistry, Metallurgy

07

D

C07D 213/64 (2006.01) A61K 31/44 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2478183

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

L'invention porte sur de nouveaux composés de formule structurelle (I) antagonistes ou agonistes inverses du récepteur cannabinoïde-1 (CB-1) s'avérant utiles dans le traitement de maladies médiées par ledit récepteur. Lesdits composés sont des médicaments à action centrale utilisables pour le traitement: des psychoses, des déficits de mémoire, des troubles cognitifs, de la migraine, des neuropathies, des troubles neuroinflammatoires dont la sclérose en plaques et le syndrome de Guillain-Barre, des séquelles inflammatoires de l'encéphalite virale, des accidents vasculaires cérébraux, des traumatismes crâniens, de l'anxiété, du stress, de l'épilepsie, de la maladie de Parkinson, des troubles de la locomotion, et de la schizophrénie. Ils s'avèrent également utiles dans le traitement de la toxicomanie, de l'obésité, des troubles de la nutrition, de l'asthme, de la constipation, des pseudo-obstructions intestinales chroniques, et de la cirrhose du foie.

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