C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/04 (2006.01) A61K 31/34 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2628542
The present invention concerns substituted aminophenylsulfonamide compounds, their use as protease inhibitors, in particular as broad-spectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present substituted aminophenylsulfonamide compounds with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.
L'invention concerne des composés aminophénylsulfonamide substitués, leur utilisation en tant qu'inhibiteurs de protéase, en particulier en tant qu'inhibiteurs de protéase du VIH à large spectre, leurs procédés de préparation ainsi que des compositions pharmaceutiques et des kits diagnostiques les comprenant. L'invention concerne également des combinaisons desdits composés aminophénylsulfonamide substitués avec un autre agent antirétroviral. L'invention concerne en outre l'utilisation desdits composés dans des analyses en tant que composés de référence ou en tant que réactifs.
Boonants Paul Jozef Gabriel Maria
de Kock Herman Augustinus
Jonckers Tim Hugo Maria
Last Stefaan Julien
Surleraux Dominique Louis Nestor Ghislain
Gowling Lafleur Henderson Llp
Tibotec Pharmaceuticals Ltd.
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