Substituted aminothiazole derivatives, pharmaceutical...

Details Substituted aminothiazole derivatives, pharmaceutical... Substituted aminothiazole derivatives, pharmaceutical...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2731442

Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.

La présente invention concerne des dérivés d'aminothiazole substitués, leurs procédés de préparation, des compositions pharmaceutiques comprenant un aminothiazole substitué et leurs procédés d'utilisation pour traiter des troubles chez l'homme ou l'animal. Ces composés peuvent se révéler utiles en tant qu'inhibiteurs de l'action de l'AgRP sur le récepteur de la mélanocortine et peuvent ainsi être utilisés pour la gestion, le traitement et l'éradication ou le traitement d'appoint de maladies pouvant réagir à la modulation des récepteurs de la mélanocortine, dont les troubles associés à l'obésité.

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