Substituted arylpyrazines

Details Substituted arylpyrazines Substituted arylpyrazines

C - Chemistry, Metallurgy

07

D

C07D 241/18 (2006.01) A61K 31/4965 (2006.01) A61P 25/00 (2006.01) C07D 241/12 (2006.01) C07D 241/20 (2006.01) C07D 241/52 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2398937

Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affiity and high selectivity to CRF1 receptors, including human CRF1 receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF1 receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.

L'invention concerne des composés arylpyrazines, comprenant des arylpyrazines pouvant se lier à des récepteurs CRF¿1? à affinité et à sélectivité élevée, ainsi qu'à des récepteurs CRF¿1? humains. L'invention concerne également des procédés de traitement de troubles et de maladies associées à ces récepteurs CRF¿1?, ainsi que des troubles et des maladies liées au système nerveux central, plus particulièrement des troubles et des maladies affectives, et neurologiques chroniques et aiguës.

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