C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/20 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 25/22 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2651825
Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF1 receptors, including human CRF1 receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF1 receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.
de Lombaert Stephane
Doller Dario
Ge Ping
Hodgetts Kevin J.
Horvath Raymond F.
Neurogen Corporation
Riches Mckenzie & Herbert Llp
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