Substituted azabicylic compounds and their use as inhibitors...

Details Substituted azabicylic compounds and their use as inhibitors... Substituted azabicylic compounds and their use as inhibitors...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/42 (2006.01) C07D 235/08 (2006.01) C07D 235/24 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2258728

This invention is directed to physiologically active compounds of formula (I) wherein (i) represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring (ii) is an azaheterocycle, and the ring (iii) represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; wherein R1-R3, A1, Z1, m and n are as defined herein. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.

L'invention concerne des composés efficaces sur le plan physiologique représentés par la formule (I), dans laquelle (i) représente un système de noyaux bicyclique comportant de 10 à 13 éléments, dans lequel le noyau (ii) représente un azahétérocycle et le noyau (iii) représente un noyau azahétéroaryle, ou le noyau de benzène éventuellement substitué par halo; R?1¿, R?3¿, A?1¿, Z?1¿, m et n sont tels qu'ils sont définis dans le descriptif. Ces compositions inhibent la production ou les effets physiologiques de TNF, ainsi que la phosphodiestérase cyclique d'AMP. L'invention concerne également des compositions pharmaceutiques contenant ces composés représentés par la formule (I), leur utilisation pharmaceutique et leurs procédés de préparation.

Affiliated with

Also associated with

Rating

Substituted azabicylic compounds and their use as inhibitors... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted azabicylic compounds and their use as inhibitors..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted azabicylic compounds and their use as inhibitors... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1362489