Substituted azole derivatives as therapeutic agents

Details Substituted azole derivatives as therapeutic agents Substituted azole derivatives as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/40 (2006.01) C07D 263/32 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01)

Patent

CA 2514363

This invention provides azoles which may be useful as inhibitors of protein tyrosine phosphatases (PTPases). The present invention provides compounds of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds and their use in treating human or animal disorders. The compounds of the invention may be useful as inhibitors of protein tyrosine phosphatases and thus can be useful for the management, treatment, control and adjunct treatment of diseases mediated by PTPase activity. Such diseases include Type I diabetes, Type II diabetes.

La présente invention se rapporte à des azoles qui peuvent être utiles en tant qu'inhibiteurs des protéine tyrosine phosphatases (PTP). L'invention a trait à des composés représentés par la formule (I), à des procédés permettant de les préparer, à des compositions pharmaceutiques les contenant et à leur utilisation pour traiter des troubles touchant les êtres humains ou les animaux. Les composés selon l'invention peuvent être utiles en tant qu'inhibiteurs des protéine tyrosine phosphatases, et peuvent ainsi servir à la gestion, au traitement, au contrôle et au traitement auxiliaire de maladies causées par l'activité des PTP. Parmi de telles maladies, on peut citer le diabète de type I et le diabète de type II.

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