Substituted benzoindoles as spla2 inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 209/00 (2006.01) A61K 31/40 (2006.01) A61P 29/00 (2006.01) C07D 209/60 (2006.01)

Patent

CA 2431023

A novel class of benz[f]indole compounds see structure (I) is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.

La présente invention concerne une nouvelle classe de composés benz[f]indole représentés par la structure (I) et leur utilisation pour inhiber la libération d'acides gras par médiation des sPLA¿2?, afin de traiter des affections inflammatoires telles que le choc septique.

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