Substituted bicyclic derivatives useful as anticancer agents

Details Substituted bicyclic derivatives useful as anticancer agents Substituted bicyclic derivatives useful as anticancer agents

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/165 (2006.01) A61K 31/437 (2006.01) A61K 31/4725 (2006.01) A61K 31/495 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 43/00 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 45

Patent

CA 2358998

The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).

Composés de formule (1) et sels et solvates desdits composés acceptables sur le plan pharmaceutique. Dans ladite formule, A, X, R<1>, R<3> et R<4> sont tels que définis dans le descriptif. La présente invention concerne également des méthodes de traitement de la croissance cellulaire anormale chez les mammifères, consistant à administrer les composés de formule (1), ainsi que des compositions pharmaceutiques, contenant les composés de formule (1), destinées à traiter lesdits troubles de la croissance cellulaire. Elle concerne également des procédés de préparation des composés de formule (1).

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