Substituted carbinol compound having a cyclic linker

Details Substituted carbinol compound having a cyclic linker Substituted carbinol compound having a cyclic linker

C - Chemistry, Metallurgy

07

D

C07D 233/72 (2006.01) A61K 31/4166 (2006.01) A61K 31/4178 (2006.01) A61K 31/4355 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/506 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 17/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 491/048 (2006.01)

Patent

CA 2725111

It is to provide a novel LXR.beta. agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. It is a carbinol compound represented by the following general formula (I) or salt thereof, or their solvate. (see formula I)

La présente invention concerne un nouvel agoniste de LXRß qui est utile en tant qu'agent prophylactique et/ou thérapeutique pour l'artériosclérose telle que l'athérosclérose et l'artériosclérose associée au diabète, la dyslipidémie, l'hypercholestérolémie, les maladies liées aux lipides, les maladies inflammatoires induites par des cytokines inflammatoires, les maladies de la peau telles que des maladies allergiques de la peau, le diabète ou la maladie d'Alzheimer.  L'agoniste de LXRß est un composé de carbinol représenté par la formule générale (I), un sel du composé de carbinol, ou un solvate du composé de carbinol ou du sel.

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